Inflammation plays a pivotal role in the immune system’s protection of tissue, organs, and function throughout the body. Many cell types and signal pathways are involved in a complex balance that retain homeostasis. A dynamic system that balances out changing factors influencing the body.
A wide range of diseases and conditions result in an inflammatory response that the body cannot resolve, as it would do in a healthy condition. This may in turn worsen the condition and result in damage to tissues, organs and function – even in some cases be lethal.
A common way to treat these diseases is to inhibit the specific pathways or cells that are causing the inflammatory response in the particular disease commonly known as immune suppression. The culprit is, however, that the very same signal pathway or cell type may play an important role in other vital parts of the body, and the immune suppression is often associated with unfavorable side effects. An important example of this is the wide use of glucocorticoids.
Our approach is to utilize and modulate the immune system, with the aim to restore homeostasis, i.e. rebalance the immune system.
To demonstate and create clinical proof of this concept we focus on
- Early Intervention
Our aim is to develop safe and effective medicines that would offer an opportunity to avoid use of glucocorticoids and avoid or postpone the use of other immunosuppressive drugs, for the benefit of the patients carrying the disease in question.